ea0093oc8 | Oral communication 1: Adrenal Diseases | EYES2023
Chifu Irina
, Richter Anna Lena
, Scheuermann Carolin
, Burger-Stritt Stephanie
, Lippert Juliane
, Herterich Sabine
, Hahner Stefanie
Introduction: Glucocorticoid (GC) replacement regimens in adrenal insufficiency (AI) only roughly correspond to physiological steroid profiles. Moreover, control of substitution quality is difficult and signs of clinically relevant mild chronic over- or under-replacement might be omitted. FKBP5 regulates GC receptor sensitivity by reducing its affinity to cortisol when bound to the receptor complex. FKBP5 methylation has been inversely correlated with cortisol levels both in h...